Wolff-Parkinson-White (WPW) syndrome is a cardiac electrophysiology (EP) disorder caused by the presence of an accessory pathway (AP) that bypasses the atrioventricular node, faster ventricular activation rate, and provides a substrate for atrio-ventricular reentrant tachycardia (AVRT). Accurate localization of the AP is critical for planning and guiding catheter ablation procedures. While traditional diagnostic tree (DT) methods and more recent machine learning (ML) approaches have been proposed to predict AP location from surface electrocardiogram (ECG), they are often constrained by limited anatomical localization resolution, poor interpretability, and the use of small clinical datasets. In this study, we present a Deep Learning (DL) model for the localization of single manifest APs across 24 cardiac regions, trained on a large, physiologically realistic database of synthetic ECGs generated using a personalized virtual heart model. We also integrate eXplainable Artificial Intelligence (XAI) methods, Guided Backpropagation, Grad-CAM, and Guided Grad-CAM, into the pipeline. This enables interpretation of DL decision-making and addresses one of the main barriers to clinical adoption: lack of transparency in ML predictions. Our model achieves localization accuracy above 95%, with a sensitivity of 94.32% and specificity of 99.78%. XAI outputs are physiologically validated against known depolarization patterns, and a novel index is introduced to identify the most informative ECG leads for AP localization. Results highlight lead V2 as the most critical, followed by aVF, V1, and aVL. This work demonstrates the potential of combining cardiac digital twins with explainable DL to enable accurate, transparent, and non-invasive AP localization.

Neural networks are part of daily-life decision-making, including in high-stakes settings where understanding and transparency are key. Saliency maps have been developed to gain understanding into which input features neural networks use for a specific prediction. Although widely employed, these methods often result in overly general saliency maps that fail to identify the specific information that triggered the classification. In this work, we suggest a framework that allows to incorporate attributions across classes to arrive at saliency maps that actually capture the class-relevant information. On established benchmarks for attribution methods, including the grid-pointing game and randomization-based sanity checks, we show that our framework heavily boosts the performance of standard saliency map approaches. It is, by design, agnostic to model architectures and attribution methods and now allows to identify the distinguishing and shared features used for a model prediction.

Explainable Artificial Intelligence (XAI) plays a crucial role in enhancing the transparency and accountability of AI models, particularly in natural language processing (NLP) tasks. However, popular XAI methods such as LIME and SHAP have been found to be unstable and potentially misleading, underscoring the need for a standardized evaluation approach. This paper introduces SCENE (Soft Counterfactual Evaluation for Natural language Explainability), a novel evaluation method that leverages large language models (LLMs) to generate Soft Counterfactual explanations in a zero-shot manner. By focusing on token-based substitutions, SCENE creates contextually appropriate and semantically meaningful Soft Counterfactuals without extensive fine-tuning. SCENE adopts Validitysoft and Csoft metrics to assess the effectiveness of model-agnostic XAI methods in text classification tasks. Applied to CNN, RNN, and Transformer architectures, SCENE provides valuable insights into the strengths and limitations of various XAI techniques.

Explanations for machine learning models can be hard to interpret or be wrong. Combining an explanation method with an uncertainty estimation method produces explanation uncertainty. Evaluating explanation uncertainty is difficult. In this paper we propose sanity checks for uncertainty explanation methods, where a weight and data randomization tests are defined for explanations with uncertainty, allowing for quick tests to combinations of uncertainty and explanation methods. We experimentally show the validity and effectiveness of these tests on the CIFAR10 and California Housing datasets, noting that Ensembles seem to consistently pass both tests with Guided Backpropagation, Integrated Gradients, and LIME explanations.

Convolutional Neural Networks (ConvNets) usually rely on edge/shape information to classify images. Visualization methods developed over the last decade confirm that ConvNets rely on edge information. We investigate situations where the ConvNet needs to rely on image intensity in addition to shape. We show that the ConvNet relies on image intensity information using visualization. Convolutional Neural Networks (ConvNets) usually rely on edge/shape information to classify images.

We apply convolutional neural networks (CNN) to the problem of image orientation detection in the context of determining the correct orientation (from 0, 90, 180, and 270 degrees) of a consumer photo. The problem is especially important for digitazing analog photographs. We substantially improve on the published state of the art in terms of the performance on one of the standard datasets, and test our system on a more difficult large dataset of consumer photos. We use Guided Backpropagation to obtain insights into how our CNN detects photo orientation, and to explain its mistakes.

Model visualizations provide information that outputs alone might miss. But can we trust that model visualizations reflect model behavior? For instance, can they diagnose abnormal behavior such as planted backdoors or overregularization? To evaluate visualization methods, we test whether they assign different visualizations to anomalously trained models and normal models. We find that while existing methods can detect models with starkly anomalous behavior, they struggle to identify more subtle anomalies. Moreover, they often fail to recognize the inputs that induce anomalous behavior, e.g. images containing a spurious cue. These results reveal blind spots and limitations of some popular model visualizations. By introducing a novel evaluation framework for visualizations, our work paves the way for developing more reliable model transparency methods in the future.

The so-called black-box deep learning (DL) models are increasingly used in classification tasks across many scientific disciplines, including wireless communications domain. In this trend, supervised DL models appear as most commonly proposed solutions to domain-related classification problems. Although they are proven to have unmatched performance, the necessity for large labeled training data and their intractable reasoning, as two major drawbacks, are constraining their usage. The self-supervised architectures emerged as a promising solution that reduces the size of the needed labeled data, but the explainability problem remains. In this paper, we propose a methodology for explaining deep clustering, self-supervised learning architectures comprised of a representation learning part based on a Convolutional Neural Network (CNN) and a clustering part. For the state of the art representation learning part, our methodology employs Guided Backpropagation to interpret the regions of interest of the input data. For the clustering part, the methodology relies on Shallow Trees to explain the clustering result using optimized depth decision tree. Finally, a data-specific visualizations part enables connection for each of the clusters to the input data trough the relevant features. We explain on a use case of wireless spectrum activity clustering how the CNN-based, deep clustering architecture reasons.

Deep learning (DL) models find increasing application in mental state decoding, where researchers seek to understand the mapping between mental states (e.g., perceiving fear or joy) and brain activity by identifying those brain regions (and networks) whose activity allows to accurately identify (i.e., decode) these states. Once a DL model has been trained to accurately decode a set of mental states, neuroimaging researchers often make use of interpretation methods from explainable artificial intelligence research to understand the model's learned mappings between mental states and brain activity. Here, we compare the explanation performance of prominent interpretation methods in a mental state decoding analysis of three functional Magnetic Resonance Imaging (fMRI) datasets. Our findings demonstrate a gradient between two key characteristics of an explanation in mental state decoding, namely, its biological plausibility and faithfulness: interpretation methods with high explanation faithfulness, which capture the model's decision process well, generally provide explanations that are biologically less plausible than the explanations of interpretation methods with less explanation faithfulness. Based on this finding, we provide specific recommendations for the application of interpretation methods in mental state decoding.

Deep learning shows high potential for many medical image analysis tasks. Neural networks can work with full-size data without extensive preprocessing and feature generation and, thus, information loss. Recent work has shown that the morphological difference in specific brain regions can be found on MRI with the means of Convolution Neural Networks (CNN). However, interpretation of the existing models is based on a region of interest and can not be extended to voxel-wise image interpretation on a whole image. In the current work, we consider the classification task on a large-scale open-source dataset of young healthy subjects -- an exploration of brain differences between men and women. In this paper, we extend the previous findings in gender differences from diffusion-tensor imaging on T1 brain MRI scans. We provide the voxel-wise 3D CNN interpretation comparing the results of three interpretation methods: Meaningful Perturbations, Grad CAM and Guided Backpropagation, and contribute with the open-source library.